Withdrawal symptoms include difficulty in concentrating and short-term memory problems, said Kenneth A. Perkins, Ph.D., professor of psychiatry, epidemiology and psychology at Pitt and principal investigator of the study. These cognitive difficulties and other symptoms often lead to relapse in the vast majority of smokers who try to quit.
The experimental compound, developed by Janssen Inc.
and known as JNJ, acts at specific nicotine receptors in the brain
involved in cognitive function, and researchers will assess whether
limiting decline in cognitive problems may decrease motivation for
tobacco and lessen the withdrawal symptoms, making it easier to quit
altogether.
Study participants will try to quit briefly during each of two
week-long periods, in which they receive JNJ during one and placebo
during the other. The difference in their ability to quit will be
compared between the JNJ and placebo periods
“Many smokers desperately want to quit, but often have a hard time
with loss of concentration, focus and short-term memory,” said Dr.
Perkins. “This compound is different than other cessation drugs and we
are excited to see if it can aid more smokers to quit successfully.”
All participants will be offered counseling and the FDA-approved cessation medication bupropion (Zyban)
at no cost to help them permanently quit once they have completed study
testing. They also will be compensated for attending study visits.
Smokers already planning to quit soon can find out more information by
calling 412-246-5306 or visiting www.SmokingStudies.pitt.edu.