Primary ovarian insufficiency

NIH. US: Primary ovarian insufficiency (POI) is the term used to describe when a woman’s ovaries stop working normally before she reaches the age of 40. POI is not the same as early or premature menopause. Many women with POI do not get monthly menstrual periods, or they have them irregularly. Problems with ovulation may make it difficult for women with POI to get pregnant. In addition, women with POI are at higher risk for certain health conditions, such as osteoporosis, than are women who do not have POI.

Study finds genetic clue to menopause-like condition in young women

NIH. US: Six young women with a disorder that mimics menopause have gene alterations that hamper the repair of damaged DNA, report researchers supported by the National Institutes of Health. The mutations, occurring in women with primary ovarian insufficiency (POI), are in genes that repair damaged DNA in cells of the ovary that eventually become egg cells. It may also contribute to understanding normal menopause.