Source: Pr Christian SAUSSINE.MD OrphanetBladder Pain Syndrome (BPS), also known is interstitial cystitis (IC) and painful bladder syndrome, is characterised by pelvic pain associated with bladder filling, pollakiuria (abnormally frequent urination) with a voiding frequency of more than eight urinations per day and more than two urinations per night, cystoscopic lesions (petechiae i.e a reddish spot containing blood that appears in inner membrane of the bladder as a result of localized hemorrhage, Hunner's ulcers i.e areas of inflammation on the bladder wall) revealed by a bladder hydrodistention test, and/or histological anomalies such as inflammatory mononuclear cell infiltrates and tissue granulation, in the absence of infection or any other pathology.