Link between serotonin and depression is a myth, says top psychiatrist

BMJ: The widely held belief that depression is due to low levels of serotonin in the brain - and that effective treatments raise these levels - is a myth, argues a leading psychiatrist in The BMJ this week. David Healy, Professor of Psychiatry, points to a misconception that lowered serotonin levels in depression are an established fact, which he describes as “the marketing of a myth.” 

locally produced serotonin breaks down the bone tissue

Serotonin, a well-known brain neurotransmitter, is produced locally in an unexpected place: the bone tissue. This has just been demonstrated by research scientists from the Combined "Bone and joints" research unit 606 (Inserm/Paris Diderot) working jointly with the biochemistry laboratory from the Lariboisière Hospital and the “Cytokines, hematopoiesis and immune response” laboratory (CNRS/University of Paris Descartes) at the Necker Hospital in Paris. Apparently, this locally produced serotonin breaks down the bone tissue. These results, published in the PNAS, suggest that medications that modulate the effects of serotonin, such as anti-depressants or migraine drugs, could in one way or the other modify the delicate balance between the formation and the destruction of bone in the organism.