Illinois: Consuming high amounts of carbohydrates and various forms of sugar during the year prior to treatment for head and neck cancer may increase patients’ risks of cancer recurrence and mortality, a new study reports. However, eating moderate amounts of fats and starchy foods such as whole grains, potatoes and legumes after treatment could have protective benefits, reducing patients’ risks of disease recurrence and death, said lead author Anna E. Arthur, a professor of food science and human nutrition at the University of Illinois.
In the study, researchers tracked the pre- and post-treatment diets
and health outcomes of more than 400 cancer patients. Participants were
followed for an average of 26 months after they were first diagnosed and
treated for squamous-cell carcinoma of the head or neck; all were
patients of the University of Michigan Head and Neck Specialized Program
of Research Excellence. The study was published recently in the
International Journal of Cancer.
Participants’ typical intake of food, beverages and supplements was
assessed for the year prior to diagnosis and for one year post-treatment
using the Harvard Food Frequency Questionnaire. Patients who consumed
the lowest amounts of simple carbohydrates – which included refined
grains, desserts and sugar-sweetened beverages – consumed about 1.3
servings daily, compared with about 4.4 servings by patients who were
considered high intake.
Patients who consumed the most total carbohydrates and sugars – in
the forms of sucrose, fructose, lactose and maltose – in the year
preceding cancer treatment were at greater risk of mortality from any
cause during the follow-up period, Arthur said.
Among the study population, the most commonly diagnosed cancers were
in the oral cavity and the oropharynx, which includes the tonsils, the
base of the tongue and surrounding tissues. More than 69 percent of
participants were diagnosed when the disease was at stage 3 or stage 4.
Patients’ average age at diagnosis was about 61.
During the follow-up period, more than 17 percent of patients
experienced recurrence of their cancer, and 42 patients died from it.
Another 70 participants died from other causes, according to the study.
Associations among carbohydrate intake and patient outcomes differed by cancer type and stage, Arthur said.
Higher mortality rates were found among people with oral cavity
cancer who consumed the greatest amounts of total carbohydrates, total
sugars and simple carbohydrates, but the researchers found no such
associations among people who had oropharyngeal cancers.
Likewise, high carbohydrate consumption and glycemic load were
significantly associated with increased risk of mortality from any cause
among people with cancers in stages 1 to 3, but not in patients with
stage 4 cancers.
“Although in this study we found that higher total carbohydrate and
total sugar were associated with higher mortality in head and neck
cancer patients, because of the study design we can’t say that there’s a
definitive cause-effect relationship,” said Arthur, who also is an
oncology dietitian nutritionist with the Carle Cancer Center at Carle
Foundation Hospital in Urbana, Illinois. “The next step would be to
conduct a randomized clinical trial to test whether carbohydrate
restriction has a protective effect on survival rates.”
Consuming a moderate amount – about 67 grams – of various forms of
fat and starchy foods daily after cancer treatment appeared to provide
some beneficial effects, lowering participants’ risks of mortality and
“Our results, along with the findings of other studies, suggest that
diet composition can affect cancer outcomes,” said co-author Amy M.
Goss, a professor of nutrition sciences at the University of Alabama,
Birmingham. “We’d like to determine if this is true using a prospective,
intervention study design and identify the underlying mechanisms. For
example, how does cutting back on sugar and other dietary sources of
glucose affect cancer growth?”
The study is believed to be the first to provide observational data
on the therapeutic potential of carbohydrate-restricted, higher fat
diets on head and neck squamous-cell cancers. Five-year survival rates
among these patients continue to be low, in part because these cancers
are often detected in later stages, putting patients at high risk of
“This observational study is noteworthy because it focuses on a
serious cancer that is difficult to treat, and little is known about how
nutrition can best help a patient battling it,” said co-author Dr.
Laura Q. Rogers, a professor of nutrition sciences at Alabama,
Birmingham. “This study reiterates the importance of additional
intervention studies that test optimal diet recommendations for cancer
The National Cancer Institute, the National Institutes of Health and
the U.S. Department of Agriculture National Institute of Food and
Agriculture co-funded the study.
Additional co-authors on the paper were Wendy Demark-Wahnefried,
William R. Carroll, Kevin R. Fontaine, Barbara A. Gower and Sharon A.
Spencer, all of the University of Alabama, Birmingham; and Alison M.
Mondul, Laura S. Rozek and Gregory T. Wolf, all of the University of
Michigan, Ann Arbor. Yi Tang Chen of the University of Illinois also
co-wrote the study.