INSERM: And what if meditation enhanced the aging process? This is suggested by the results of a pilot study, conducted by Inserm researchers based in Caen and Lyon. 73 individuals, with an average age of 65 years, underwent brain imaging tests. Among these individuals, “meditation experts” (with 15,000 to 30,000 hours of meditation to their name) showed significant differences in certain regions of the brain. By reducing stress, anxiety, negative emotions and sleep problems, which tend to become more pronounced with age, meditation could reduce the harmful effects arising from these factors and have a positive effect on brain aging. These results have been published in the journal Scientific Reports.
With age, brain volume and glucose metabolism gradually decrease,
resulting in declining cognitive function. These physiological changes
may be exacerbated by stress and poor sleep quality. The latter two
parameters are considered to be risk factors for Alzheimer’s disease.
Acting on stress and sleep could therefore be one of many helpful
approaches in order to delay the onset of the disease as far as
possible. One line of research, notably conducted at Inserm, focuses on
the role of meditation to achieve this goal.
Hence, a pilot study conducted by Inserm researchers from Caen and
Lyon explored the possibility that meditation is able to delay the age
at which brain changes conducive to the development of Alzheimer’s
disease appeared, by a few years. They thus studied brain function in
6 individuals who practiced meditation. “The ‘experts’ taking part
in the study had an average age of 65 years and had accumulated between
15,000 and 30,000 hours of meditation. We selected these subjects
because they practice meditation based on different Buddhist traditions,
which allowed us to create a representative panel,” explains Gaël
Chételat, Inserm researcher and lead author for these studies. The
researchers then compared their brain function with 67 control subjects,
who did not practice meditation, also with an average age of 65 years. A
broader group comprising 186 individuals aged 20 to 87 years was also
included, to evaluate the classic effects of aging on the brain, and to
shed light on the specific effects of meditation.
All individuals taking part in this study underwent neurological MRI
and PET examinations at the Cyceron biomedical imaging platform in Caen.
Significant differences were evidenced in the volume of gray matter and
glucose metabolism. The detailed results of the tests show that the
frontal and cingulate cortex and insula in the individuals who practiced
meditation were larger in volume and/or had a stronger metabolism than
the control subjects, even when differences in terms of level of
education or lifestyle were taken into account. “The brain regions
detected with a larger volume or stronger metabolism in the individuals
who practiced meditation are specifically those which decline the most
with age,” explains Gaël Chételat. The effects of age evaluated in
this study among individuals who do not meditate, aged 20 to 87 years,
were effectively concentrated in certain highly specific regions – the
same as those which were preserved among elderly individuals who
These initial results suggest that meditation could reduce the
harmful effects of these factors on the brain, and have a positive
effect on brain aging, possibly by reducing stress, anxiety, negative
emotions, and sleep problems which tend to become more pronounced with
Evidently, this is a pilot study, hence these findings will need to
be repeated on larger population samples in order to obtain more robust
results. Furthermore, the researchers are also endeavoring to shed light
on the mechanisms allowing mediation to have this positive impact on
The researchers behind this study were awarded EUR 6 million in
funding by the European Commission to complete a larger scale study on
aging well, known as the Silver Santé Study
(https://silversantestudy.fr/). This project will shed light on the
lifestyle factors for aging well, and will test the benefits of brain
training in meditation or learning English with regard to mental health
and wellbeing among seniors. It is coordinated by Inserm (Gaël Chételat,
U1237, Caen) and brings together ten partners in 6 European countries
(France, Switzerland, the United Kingdom, Germany, Belgium, and Spain).
The initial results should come to light in 2019.