UCLA geneticists have created a technique to hunt for hormones that influence how organs and tissues communicate with each other. The method enabled them to find naturally occurring molecules that play major roles in Type 2 diabetes, obesity and cardiovascular disease.In particular, they discovered:
- Two hormones called “notum” and “lipocalin-5” that speed up the body’s ability to burn fat.
- Lipocalin-5 protected mice from developing diabetes — or cured the disease after they developed it.
- Lipocalin-5 also enhanced muscle tissue’s ability to metabolize and absorb dietary nutrients, reducing the risk of obesity and diabetes.