computational modeling approach to help answer these questions. They tested the approach on a patient who had suffered a stroke. The team first measured how the patient walked at his preferred speed on a treadmill. Using those measurements, they then constructed a neuromusculoskeletal computer model of the patient that was personalized to the patient’s skeletal anatomy, foot contact pattern, muscle force generating ability, and neural control limitations. Fregly and his team found that the personalized model was able to predict accurately the patient’s gait at a faster walking speed, even though no measurements at that speed were used for constructing the model.
“This modeling effort is an excellent example of how computer models can make predictions of complex processes and accelerate the integration of knowledge across multiple disciplines,” says Grace Peng, Ph.D., director of the NIBIB program in Mathematical Modeling, Simulation and Analysis.Fregly and his team believe this advance is the first step toward the creation of personalized neurorehabilitation prescriptions, filling a critical gap in the current treatment planning process for stroke patients. Together with devices that would ensure the patient is exercising using the proper force and torque, personalized computational models could one day help maximize the recovery of patients who have suffered a stroke.
"Through additional NIH funding, we are embarking with collaborators at Emory University on our first project to predict optimal walking treatments for two individuals post-stroke,” says Fregly. “We are excited to begin exploring whether model-based personalized treatment design can improve functional outcomes."
. Andrew J. Meyer, Ilan Eskinazi, Jennifer N. Jackson, Anil V. Rao, Carolynn Patten,
Benjamin J. Fregly. Frontiers in Bioengineering and Biotechnology. 2016 Oct 13.