Pediatric Gastroenterology and Nutrition: Even after a year on a gluten-free diet, nearly 20 percent of children with celiac disease continue to have intestinal abnormalities (enteropathy) on repeat biopsies, reports a study in the Journal of Pediatric Gastroenterology and Nutrition, official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. The journal is published by Wolters Kluwer.
Symptom status and laboratory results do not predict which children
will have persistent celiac enteropathy despite a gluten-free diet,
according to the new research by Dr. Maureen Leonard of MassGeneral
Hospital for Children, Boston. "These findings suggest that a
revisitation of monitoring and management criteria of celiac disease in
childhood," Dr. Leonard comments.
New Questions on Assessing Response to Gluten-Free Diet in Celiac Disease
The researchers reviewed the records of 103 children and adolescents
with celiac disease treated at two medical centers. Patients with celiac
disease have a characteristic pattern of intestinal damage caused by
exposure to gluten, contained in wheat and other grains.
The main treatment for celiac disease is a gluten-free diet—careful
elimination of all gluten-containing foods from the diet. The children
in the study had followed a gluten-free diet for an average of 2.4
years. About 90 percent were rated as having "excellent" adherence to
The children also underwent intestinal endoscopy and biopsy (sampling
of intestinal tissue) at least two times: when celiac disease was
diagnosed and after at least one year on a gluten-free diet. The main
reasons for repeat biopsy were persistent or new symptoms or abnormal
laboratory test results.
The study focused on the rate of persistent celiac enteropathy:
gluten-induced damage to intestinal cells. Current guidelines for celiac
disease treatment rely on laboratory tests to assess healing, rather
than follow-up endoscopy and biopsy.
The repeat biopsy results showed persistent celiac enteropathy in 19
percent of children. The presence of enteropathy could not be predicted
by the presence of symptoms or by levels of IgA tissue transglutaminase
antibodies (IgA tTG)—the main laboratory test used for monitoring celiac
disease. At the time of the second biopsy, IgA tTG was elevated in 43
percent of children with persistent enteropathy and 32 percent with
In the past, children with celiac disease had routine follow-up
biopsies to monitor healing in response to a gluten-free diet. In more
recent years, laboratory tests such as IgA tTG have been used instead of
biopsies. The study was prompted by growing evidence that many adults
with celiac disease have persistent enteropathy, despite having no
symptoms and normal IgA tTG levels.
The results suggest that 1 out of 5 children with celiac disease may
have persistent enteropathy, despite following their recommended
gluten-free diet. Dr. Leonard and colleagues write: "While the long-term
effects are not known, persistent enteropathy may predispose pediatric
patients with celiac disease to future complications and suboptimal
While current guidelines do not recommend repeat biopsy, Dr. Leonard
and colleagues note that it is the only way to confirm that celiac
enteropathy has resolved. "These findings suggest the need not only for a
baseline endoscopy to confirm the diagnosis of celiac disease but also
consideration of a repeat biopsy to evaluate for remission," the
researchers add. They call for further studies to confirm their
findings, to better understand the response to a gluten-free diet, and
to evaluate further treatment options.
Click here to read “Value of IgA tTG in Predicting Mucosal Recovery in Children with Celiac Disease on a Gluten Free Diet.”
Article: “Value of IgA tTG in Predicting Mucosal Recovery in Children
with Celiac Disease on a Gluten Free Diet” (doi: