Louvain: Pr Jean-Luc Balligand from the Institute for Experimental and
Clinical Research from UCL will coordinate a european research project to
test a new therapeutic concept in the field of cardiac diseases. Based on the data of experimental research conducted over the last 10
years within his team, Pr Jean-Luc Balligand proposes a new approach
for the treatment of specific features of heart failure. The innovative
process consists in the activation of a heart cell receptor, called
beta3-adrenergic, using a drug already prescribed in urology, but which
has so far never been used in patients with heart failure.
Patients with cardiovascular risk factors such as hypertension or
obesity may develop a form of heart failure called "with preserved
ejection fraction". This is a very common disease among the elderly,
especially women. It is often accompanied by a heart muscle hypertrophy
gradually hindering the proper filling of the heart chambers. There is
currently no specific treatment for patients suffering from this
pathology, beyond the control of risk factors. Activation of
beta3-adrenergic cardiac receptors represents a novel target for this
disease.
Pre-clinical studies on mice have already shown the benefit of the
activation of this receptor on the reduction of the hypertrophy and
fibrosis of the heart muscle. The european multicenter study coordinated
by Prof. Jean-Luc Balligand will allow the initial validation of these
pre-clinical observations in a Phase IIb trial on patients, partly
recruited from the cardiovascular pathology department of the Cliniques
Universitaires Saint-Luc, suffering from myocardial hypertrophy and at
risk of developing this particular form of heart failure. The objective
of this study is to test over 12 months the possible additional
beneficial effect of the new molecule in this original cardiac
indication ("drug re-purposing"). To this end, researchers will analyze
the quantitative change of myocardial hypertrophy assessed by magnetic
resonance (CMR) and the diastolic ventricular function, measured by
Doppler echocardiography.
In summary, the study aims at the validation of an original experimental
concept whose clinical translation would represent a significant
advance in the treatment of a major health problem.