Cochrane: Flu infection may make cardiovascular disease (e.g. heart attack, stroke) and associated death more likely, and flu vaccination may reduce this risk. We included randomised studies comparing people receiving flu vaccine with those receiving no vaccine (placebo or no treatment). In patients with cardiovascular disease, influenza vaccination may reduce cardiovascular mortality and combined cardiovascular events. However, studies had some risk of bias,
and results were not always consistent, so additional higher-quality
evidence is necessary to confirm these findings. Not enough evidence was
available to establish whether influenza vaccination has a role to play
in the primary prevention of cardiovascular disease.