Queensland: Bubbles invisible to the naked eye could provide the next breakthrough in treating heart and eye problems – and present an alternate treatment for cancer and cellulite as well. University of Queensland pharmacy researcher Dr Harendra Parekh is confident his team’s nanobubble technology can be applied across a number of diseases, limiting highly toxic or expensive medicines.
“Some drug companies will be very unhappy with me, I suspect,” Dr Parekh said.
But he cautioned that the technology would not be available for
clinical use for at least 3-4 years, though it has been proven the
ultrasound approach is safe to the eye.
“Our work focuses on injecting highly-stable, pre-engineered
nanobubbles which have the potential to penetrate far deeper into
tissues assisted by non-invasive and harmless ultrasound,” he said.
“In some eye diseases for example, you won’t need to have $2000
injections, where the vast majority of drug fails to reach the retina.
“Current therapy is not only expensive, but it’s largely ineffective."
The nanobubbles are imploded by ultrasound, creating temporary
microscopic openings that enable the drug to transfer normally
“Stability tests show that the nanobubbles are very resilient, stable
enough to remain intact for many months, which is important from a
commercial perspective,” Dr Parekh said
“What’s more, each component of the system is already approved for
human use. It’s how the components are combined and re-engineered that
Dr Parekh said his team had made significant headway towards
developing an effective treatment for retinal diseases, such as
age-related macular degeneration.
“Macular degeneration costs Australia $2.8 billion a year,” he said.
“Imagine a scenario where you use a tenth of the standard drug dose
we use today, merely by combining the drug with our nanobubbles then
triggering them with ultrasound in the tissue you need to treat.
“This has the potential to revolutionise cancer chemotherapy too,
with diminished side-effects and far shorter treatment regimens
Researchers from Brazil have expressed interest in adapting the
approach for the cosmetics market, and an Indian government agency
provided AU$100,000 seed funding to Dr Parekh in 2013, to develop it as a
treatment modality for cancer.
To make a tax deductible donation to Dr Parekh’s work please visit this page.