Maastricht: Young people with autism spectrum disorder (ASD) are five times
more likely to develop psychoses or bipolar disorder as their peers.
This according to a study led by Jean-Paul Selten, Extraordinary
Professor of Social Exclusion and Psychiatric Disorders at Maastricht
University, which will be published in JAMA Psychiatry on 25 March. This
is the first time this relationship has been examined in a large cohort
study.
Selten conducted the study with Swedish and
British colleagues based on the Stockholm Youth Cohort. ‘Thanks to this
comprehensive dataset, we were able to conduct a ten-year study on more
than 9000 people who were diagnosed with autism spectrum disorder before
they turned sixteen,’ explains Selten. ‘This group was five times more
likely to develop psychosis or bipolar disorder compared to their peers
without ASD. Interestingly, young ASD patients who perform well in
school have the highest risk of developing psychosis, up to eighteen
times higher in fact.’ A psychosis is a combination of symptoms that
includes delusions and hallucinations. Patients with bipolar disorder
experience manic, hypomanic and depressive episodes, alternating with
asymptomatic periods.
Prevention
It is
unclear why this group is at such greatly increased risk of psychosis.
‘There is some evidence to suggest a genetic link between autism and
psychosis or bipolar disorder,’ Selten explains. ‘The stress of an
autism disorder, which often results in social exclusion, most likely
plays an important role. This also provides opportunities for
prevention, such as therapy or counselling. It’s important that
therapists are made aware of this increased risk, particularly among
young people who do well in school.’
Selten argues that the results
of this study using Swedish data can also be applied in the Netherlands,
where 30,000 to 60,000 people aged zero to twenty are diagnosed with
autism spectrum disorder.
Click here
to read the full article ‘Risk for Nonaffective Psychotic Disorder and
Bipolar Disorder in Young People With Autism Spectrum Disorder, A
Population-Based Study’.