Adelaide university. Australia: Patients whose low-density lipoprotein (LDL) (or bad) cholesterol levels
do not respond to cholesterol-lowering statin drugs may have more
artery blockages than those whose cholesterol levels drop with
treatment, a recent study has shown.
The study was led by Professor Steve Nicholls, Heart Health Theme Leader at the South Australian Health and Medical Research Institute (SAHMRI) and Professor of Cardiology at the University of Adelaide.
The results were published last week in in the American Heart Association journal, Arteriosclerosis, Thrombosis and Vascular Biology.
The
study showed that one in five patients treated with a statin have
minimal lowering of LDL cholesterol, which can clog arteries and
increase the risk of heart attack or stroke.
Researchers
analysed data from seven clinical studies on 647 patients with diagnosed
coronary artery disease (CAD) who were prescribed statin drugs to help
lower cholesterol. The studies compared diseased arteries before and
after statin treatment.
The study showed that LDL cholesterol
levels had either decreased (minimally), stayed the same or increased in
20 per cent of patients. They had more plaque build up in their
arteries than patients who responded to statin therapy.
Professor
Nicholls said that a lot of this is likely to be driven by using a
suboptimal statin dose, but it also shows that other cholesterol
lowering approaches to complement statin therapy in patients may be
required.
“Monitoring cholesterol levels is vital, in addition to maximising statin therapy,” Professor Nicholls added.
“The potential use of other lipid lowering agents can then be considered.
“Ultimately,
there are other LDL-lowering therapies undergoing evaluation in
clinical trials, which may be particularly useful here.
“We will
continue to do research to understand how statins work, how to more
effectively use established therapies in clinical practice and to
develop and evaluate novel approaches to cholesterol lowering that will
complement statin therapy,” he said.