UCR: Scientists shows GM soybean oil is as unhealthy as conventional soybean oil, with one benefit: no resistance to insulin. Soybean oil accounts for more than 90 percent of all the seed oil production in the United States. Genetically modified (GM) soybean oil, made from seeds of GM soybean plants, was recently introduced into the food supply on the premise that it is healthier than conventional soybean oil. But is that premise true?
Just barely, say scientists at the University of California,
Riverside and their colleagues at UC Davis. The researchers compared the
effects of both oils in experiments performed in the lab on mice. They
found that the GM soybean oil is just as unhealthy as regular soybean
oil in that it also induces obesity, diabetes and fatty liver. GM
soybean oil does, however, have one advantage: it does not cause insulin
resistance – the inability to efficiently use the hormone insulin.
“While genetic modification of crops can introduce new beneficial
traits into existing crops, the resulting products need to be tested for
long-term health effects before making assumptions about their impact
on human health,” said senior investigator Frances Sladek, a professor of cell biology and neuroscience at UC Riverside.
Study results will be presented tomorrow, March 6, at the Endocrine Society’s 97th annual meeting, currently taking place in San Diego, Calif., by Poonamjot Deol, an assistant project scientist in the Department of Cell Biology and Neuroscience who is driving the project in the Sladek lab.
Naturally high in unsaturated fats, vegetable oils were once thought
to be healthy, and were hydrogenated to increase their shelf-life and
temperature stability. The hydrogenation, however, generated trans fats – now widely recognized as being unhealthy.
Soybean oil, the most common vegetable oil used in the United States,
contains about 55 percent linoleic acid, a polyunsaturated fat.
“Our previous results on mice showed that replacing some of the fat
in a diet high in saturated fats from coconut oil with soybean oil – to
achieve a level common in the American diet – causes significantly more
weight gain, adiposity, diabetes and insulin resistance than in mice fed
just the high-fat coconut oil diet,” Sladek said.
To determine whether linoleic acid was responsible for the metabolic
effects of soybean oil, the researchers designed a parallel diet in
which regular soybean oil was replaced, on a per gram basis, with GM
soybean oil. The GM soybean oil has a fatty acid composition (low
linoleic acid) similar to that of olive oil. The GM plants were
developed by DuPont to reduce trans fat production, increase soybean oil shelf life and create a generally healthier cooking oil.
“The GM soybean oil has 0 grams trans fat and more of the
monounsaturated fats that are considered heart healthy,” Deol said. “But
it had not been tested for long term metabolic effects until our
Deol and the rest of the research team found to their surprise that
the parallel diet containing GM soybean oil induced weight gain and
fatty liver essentially identical to that of a diet with regular soybean
oil, with the exception that the mice remained insulin sensitive and
had somewhat less adipose (fat) tissue.
“These results indicate that linoleic acid may contribute to insulin
resistance and adiposity but that another as yet unidentified component
of the soybean oil affects the liver and overall weight gain,” Deol
In their experiments, the researchers gave four groups of mice
different diets for 24 weeks. Each group was comprised of 12 mice. The
control group received a low-fat diet (5 percent of daily calories from
fat). The other groups received a diet with 40 percent of daily
calories from fat, an amount common in the American diet. One diet was
high in saturated fat from coconut oil, and one had 41 percent of the
saturated fat replaced with regular soybean oil. The fourth group had
41 percent of the saturated fat replaced with the GM soybean oil. The
body weights, food intake, glucose tolerance and insulin sensitivity of
all the mice were tracked.
What the researchers found was that mice fed a diet with either of
the soybean oils had worse fatty liver, glucose intolerance and obesity
than the group that got all their fat from coconut oil. But the mice
whose diet included the GM soybean oil had less fat tissue than the
animals that ingested regular soybean oil. These mice weighed about 30
percent more than the controls that ate a low-fat diet, while the group
on the diet containing regular soybean oil weighed 38 percent more than
controls. The mice on the diet that was primarily coconut oil weighed
only about 13 percent more than controls. Unlike the diet with regular
soybean oil, the diet with the new GM soybean oil did not lead to
“While the GM soybean oil may have fewer negative metabolic
consequences than regular soybean oil, it may not necessarily be as
healthy as olive oil, as has been assumed by its fatty acid composition,
and it is certainly less healthy than coconut oil which is primarily
saturated fat,” Sladek said. “It is important to understand the
metabolic effects and health impact of the GM soybean oil before it is
widely adopted as a healthier alternative to regular soybean oil. It is
equally important to understand the health effects of regular soybean
oil, which is ubiquitous in the American diet and seems to be much more
detrimental to metabolic health than saturated fat.”
Sladek and Deol were joined in the research by Jane R. Evans, Antonia
Rizo and Cynthia Perez at UCR; and Johannes Fahrmann, Dimitry Grapov,
Jun Yang and Oliver Fiehn at UC Davis who performed extensive analysis
on the liver and blood samples from these mice.
“To our knowledge this is the first in-depth analysis of the
metabolic effects of GM soybean oil, and the first metabolomics analysis
comparing soybean oil – regular and GM – to coconut oil,” Deol said.
The research was supported by a UCR Collaborative Seed Grant as well
as grants from the UCR Agricultural Experiment Station, and the UC Davis
West Coast Metabolomics Center, funded by the National Institutes of
Health. Deol was supported by a training grant from the National
Institute of Environmental Health Sciences.