Auckland: An exciting new technology for the delivery of peptides to skin cells has been developed at the University of Auckland. “This is potentially a break-through peptide technology,” says the
head of the University’s School of Pharmacy, Professor Julia Kennedy.
“Obtaining a biological response from applying substances through the
skin is very difficult to achieve and approaches can be extremely
expensive.”
The novel drug delivery carrier system allows the peptides to be
delivered direct to the targeted cells through the skin which is
normally seen as a relatively impervious covering and is rarely used for
drug delivery.
“This area of research has been notoriously difficult to work in,”
she says. “The technology, which is based on a ‘cellular delivery’
approach, is now subject to a patent application by the New
Zealand-based skin care company Snowberry that co-sponsored the
research.”
The technology has taken four years to develop, led by Dr Zimei Wu
from the School of Pharmacy who also supervised research by doctoral
student, Travis Badenhorst. They had scientific support from
pharmaceuticals scientist, Dr Darren Svirskis.
“Drs Wu and Svirskis are thrilled with the success of their
technology which has demonstrated that highly beneficial peptides have
been delivered to skin cells and have been shown to boost collagen and
elastin production, in a way it is believed has never been done before”,
says Professor Kennedy.
“It’s exciting that this research has produced a technology that has
the potential for wide biological application, such as vaccination
delivery through topical application,” she says.
The project started by investigating the physicochemical properties
of the wound healing / anti-aging peptide and identifying issues with
getting the peptide into the skin. A nano-formulation approach was
developed using niosomes to transport the peptide into the skin.
“We were able, in both cell lines and human skin, to see that the
nano-formulation transported the peptide into the skin, delivered the
payload into the cells and that a biological response was elicited,”
says Dr Svirskis.
The first application of this technology has been to incorporate it
into a face serum (developed in partnership with Snowberry) and the
results of a human trial of this product will be presented in a podium
presentation by PhD student,Travis Badenhorst to the World Congress of
Dermatology in Vancouver in June this year.
For media enquiries email s.phillips@auckland.ac.nz