UTSW. US: A device that measures movement and balance can effectively help assess
and track the progression of Parkinson’s disease, even when medications
are used to reduce Parkinson’s symptoms, UT Southwestern Medical Center
research found.
Researchers found that the APDM Mobility Lab – a portable set of
sensors that track gait, balance and other movement – can effectively
help clinicians estimate the depth and severity of the neurological
disorder in affected individuals, even while patients are taking
medications to control trembling and other symptoms. The findings appear
in the Journal of the Neurological Sciences.
“Objective assessment tools for Parkinson’s disease are needed to accelerate progress in developing effective therapies,” said Dr. Richard Dewey, Jr., Professor of Neurology and Neurotherapeutics, Clinical Director of the Clinical Center for Movement Disorders
at UT Southwestern, and senior author of the study. “We might be able
to actually measure the patient’s progress or regression thoroughly and
objectively.”
Parkinson’s disease is a progressive neurological disorder
characterized by trembling in the hands, arms, legs, jaw, and face;
rigidity or stiffness; and balance and coordination difficulties.
According to the Parkinson’s Disease Foundation, more than 10 million
people worldwide and more than 1 million in the U.S. live with the
disease. Approximately 60,000 people in the U.S. are diagnosed with
Parkinson's disease each year – most often people age 50 and older and
more frequently men than women. At present, there is no cure for
Parkinson’s disease.
Medications target symptoms, but the disease can be difficult to
diagnose accurately. There are currently no blood or laboratory tests
that have been proven to help in diagnosing sporadic Parkinson’s disease
and diagnosis is typically based on medical history and a neurological
examination and observation, according to the Foundation.
The APDM Mobility Lab uses wearable sensors and sophisticated signal
processing to track even subtle changes in gait, stride, balance,
rotation, and efficiency and range of movement in upper and lower limbs
and torsos. The system is typically used for athletic training and by
universities for research and evaluation.
The UT Southwestern findings evolved from a clinical trial comparing
135 individuals with Parkinson’s disease and 66 people without the
disorder. Participants performed two tasks designed to assess gait and
balance while connected to the APDM Mobility Lab through six small
sensors on the limbs, chest, and lumbar area. The study was supported by
the National Institutes of Neurological Disorders and Stroke Parkinson
Disease Biomarker Program.
Dr. Thomas McConnell, who has early-stage Parkinson’s disease, was a participant in the clinical trial.
“I understand the necessity of good research to advance medical care
and treatment,” said Dr. McConnell, a Clinical Professor of Pathology at
UT Southwestern. “This is a diagnostic trial, not therapeutic. But now
we have hope for an earlier and more certain diagnosis of Parkinson’s
disease, and identifying the most effective treatment.”
Other UT Southwestern contributors include Dr. Ira Bernstein, Clinical Professor of Clinical Sciences; Dr. Pravin Khemani, Assistant Professor of Neurology and Neurotherapeutics; Richard B. Dewey III, a third-year medical student; Dr. Ross Querry, Associate Professor of Physical Therapy and Orthopaedic Surgery; and Dr. Shilpa Chitnis, Associate Professor of Neurology and Neurotherapeutics.
The Clinical Center for Movement Disorders
at UT Southwestern is a tertiary referral center that accommodates more
than 4,000 patient visits each year. The center’s physicians have
extensive experience with patients with Parkinson's disease,
Huntington's disease, tremor disorders, tic disorders, and dystonia. The
multidisciplinary center works closely with complimentary services such
as psychiatry, and speech, physical, and occupational therapy to
provide comprehensive care for patients.
About UT Southwestern Medical CenterUT Southwestern, one
of the premier academic medical centers in the nation, integrates
pioneering biomedical research with exceptional clinical care and
education. The institution’s faculty includes many distinguished
members, including six who have been awarded Nobel Prizes since 1985.
Numbering approximately 2,800, the faculty is responsible for
groundbreaking medical advances and is committed to translating
science-driven research quickly to new clinical treatments.
UT Southwestern physicians provide medical care in 40 specialties to
about 92,000 hospitalized patients and oversee approximately 2.1 million
outpatient visits a year.