In the Smart Organic Materials Laboratory
at Academia Sinica, Hsiao-hua Yu, Associate Research Fellow of the
Institute of Chemistry, and Hsian-Rong Tseng from the California
NanoSystems Institute at UCLA have developed a way to capture CTCs from
blood samples – a liquid biopsy – and then release them from the surface
with great cell viability using an invention called the Nano Velcro
chip. This allows the scientists to examine the CTCs and analyze their
genetic features. The study was published online on December 13, 2014 in
the journal ACS Nano.
The Thermoresponsive Nano Velcro CTC
purification system, developed by Yu and his colleagues allows them to
raise the temperature to adhere the cells, then lower it to release
them. This method makes the process for extracting CTCs much more
efficient and cost-effective at a time in a patient’s life when doctors
need as much information as possible and as quickly as possible.
Moreover, mutational genetic analysis is successfully demonstrated to
monitor the disease evolution of a sample lung cancer patient. This
shows the translational value of the device in managing non-small cell
lung cancer with underlying mutations.
“Cancer cells are constantly changing
with the microenvironment. Therefore it is difficult to manage and track
their molecular biological status. With our new system we can control
the temperature like an espresso machine for blood to capture then
release the target cells,” said Yu. “The downstream cellular mutational
analysis will reveal information about the cancer status. As a result,
the information will lead to a cancer GPS system to detect cancers with
underlying mutations, locate their status in the complex cancer-biology
map, and subsequently guide medical treatments”
This research was supported by Academia
Sinica, the Academia Sinica Research Project on Nanoscience and
Technology, RIKEN (Japan), the National Institutes of Health (USA), Sun
Yat-Sen University (China) and the National Natural Science Foundation
of China.
The full article is entitled “Programming Thermoresponsiveness of
NanoVelcro Substrates Enables Effective Purification of Circulating
Tumor Cells in Lung Cancer Patients” and is available at the ACS Nano
website at:http://pubs.acs.org/doi/pdf/10.1021/nn5056282
The full list of authors is: Zunfu Ke, Millicent Lin, Jie-Fu Chen, Jin-sil Choi, Yang Zhang, Anna Fong, An-Jou Liang, Shang-Fu Chen, Qingyu Li, Wenfeng Fang, Pingshan Zhang, Mitch A. Garcia, Tom Lee, Min Song, Hsing-An Lin, Haichao Zhao, Shyh-Chyang Luo, Shuang Hou, Hsiao-hua Yu, and Hsian-Rong Tseng
Media contacts:
Dr. Hsiao-hua (Bruce) Yu, Associate Research Fellow, Smart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, bruceyu@gate.sinica.edu.tw (Tel) +886-2-2789-8634
Ms. Pearl Huang, Office of the Secretary-General, Central Office of Administration,
Academia Sinica, pearlhuang@gate.sinica.edu.tw
(Tel) +886-2-2789-8820 (Fax) +886-2-2782-1551 (M) 0912-831-188
Ms. Mei-hui Lin, Office of the Secretary-General, Central Office of Administration,
Academia Sinica, mhlin313@gate.sinica.edu.tw
(Tel) +886-2-2789-8821 (Fax) +886-2-2782-1551 (M) 0963-712-720
Release Unit : Office of the Secretary-General
最後更新：中華民國104年01月12日