Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive muscular paralysis reflecting degeneration of motor neurones. The mean age of onset is about 60. ALS usually present with dysarthria and dysphagia for solid or liquids (bulbar onset), and limb symptoms (muscle weakness and spasticity). Paralysis is progressive and leads to death due to respiratory failure within 2–3 years for bulbar onset cases and 3–5 years for limb onset ALS cases.
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