Lund University: Through
a detailed study of leukaemia cells from more than 200 children, a
research group at Lund University in Sweden has discovered two new types
of childhood leukaemia. Using next-generation sequencing technology
(NGS), the researchers were able to study the genome of cancer cells,
which is how they discovered the new types of cancer. Acute
lymphoblastic leukaemia is a rare disease, but the most common form of
cancer in children. Today the treatment is very successful, but requires
heavy interventions at the risk of causing many side effects. There is
therefore a need to distinguish between different types of acute
lymphoblastic leukaemia, in order to adapt the treatment according to
the severity of each case, and to detect possible relapse.
“Like
all types of cancer, childhood leukaemia is caused by genetic mutations
in normal cells, which are then transformed into cancer cells. Finding
the critical mutations in the diseased cells is an important condition
for understanding the mechanisms of the disease and ultimately
discovering new therapies”, explains Thoas Fioretos, professor and
senior consultant at the Division of Clinical Genetics, and Principal
investigator of the project
Through the relatively new next-generation sequencing method, the researchers were able to examine the changes that occur in cancer cells in greater detail, which is how they discovered the two new types of childhood leukaemia.
“One type occurs when a gene called DUX4, which is normally inactive in blood cells, becomes activated when the gene is relocated in the genome. The second type resembles a previously known type of childhood leukaemia, but is caused by other genetic mutations”, says Henrik Lilljebjörn, researcher and project manager of the study.
Previous studies of childhood acute lymphoblastic leukaemia have shown that there are six major groups of acute lymphoblastic leukaemia in children. The discovered two new types, together representing about 10 per cent of all childhood leukaemia, can now be added to these groups.
“Over the last few years, our research group has worked extremely intensely on this study, which would not have been possible without collaboration with several other researchers at Lund University, Skåne University Hospital, and research groups in Germany”, concludes Thoas Fioretos.
The hope is that the findings will lead to improved diagnosis and monitoring of childhood leukaemia, and ultimately new forms of treatment. The research group’s findings are published in the prestigious journal Nature Communications.
The two new types of leukaemia are called “DUX4-rearranged” and "ETV6/RUNX1-like”.
The research article is published in Nature Communications
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in pediatric B-cell precursor acute lymphoblastic leukaemia
Through the relatively new next-generation sequencing method, the researchers were able to examine the changes that occur in cancer cells in greater detail, which is how they discovered the two new types of childhood leukaemia.
“One type occurs when a gene called DUX4, which is normally inactive in blood cells, becomes activated when the gene is relocated in the genome. The second type resembles a previously known type of childhood leukaemia, but is caused by other genetic mutations”, says Henrik Lilljebjörn, researcher and project manager of the study.
Previous studies of childhood acute lymphoblastic leukaemia have shown that there are six major groups of acute lymphoblastic leukaemia in children. The discovered two new types, together representing about 10 per cent of all childhood leukaemia, can now be added to these groups.
“Over the last few years, our research group has worked extremely intensely on this study, which would not have been possible without collaboration with several other researchers at Lund University, Skåne University Hospital, and research groups in Germany”, concludes Thoas Fioretos.
The hope is that the findings will lead to improved diagnosis and monitoring of childhood leukaemia, and ultimately new forms of treatment. The research group’s findings are published in the prestigious journal Nature Communications.
The two new types of leukaemia are called “DUX4-rearranged” and "ETV6/RUNX1-like”.
The research article is published in Nature Communications
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in pediatric B-cell precursor acute lymphoblastic leukaemia