Scimex: Sleeping plays an important role in forming lasting memories, but
controversy remains over whether the sleeping brain helps to create
these memories by deleting unnecessary connections or by strengthening
important ones. Now new animal research suggests that both processes
occur during sleep. Sleep is important for long lasting memories, particularly during this exam season. Research publishing in PLOS Computational Biology suggests
that sleeping triggers the synapses in our brain to both strengthen and
weaken, which prompts the forgetting, strengthening or modification of
our memories in a process known as long-term potentiation (LTP).
Researchers
led by Sidarta Ribeiro at the Brain Institute of the Federal University
of Rio Grande do Norte, Brazil, measured the levels of a protein
related to LTP during the sleep cycle of rats. The authors then used the
data to build models of sleep-dependent synaptic plasticity.
The
results show that sleep can have completely different effects depending
on whether LTP is present or not. A lack of LTP leads to memory erasure,
while the presence of LTP can either strengthen memories or prompt the
emergence of new ones.
The research provides an empirical and
theoretical framework to understand the mechanisms underlying the
complex role of sleep for learning, which involves selective remembering
as well as creativity.